INHIBITION OF PEPTIDYL-ARGININE DEIMINASES REVERSES PROTEIN-HYPERCITRULLINATION AND DISEASE IN MOUSE MODELS OF MULTIPLE SCLEROSIS

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

SUMMARY Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy.We first discovered that abnormal myelin hypercitrullination, even in normal-appearing white matter, by peptidylarginine deiminases (PADs) correlates strongly with disease severi

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Metal air pollution partnership solutions: building an academic-government-community-industry collaboration to improve air quality and health in environmental justice communities in Houston

Abstract Background From 2006 to 2011, the City of Houston received nearly 200 community complaints about air pollution coming from some metal recycling facilities.The investigation by the Houston Health Department (HHD) found that while operating within legal limits, emissions from facilities that use torch cutting, a technique generating metal ae

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GIS for the needs of the Radioactive Waste Repository Authority

The Radioactive Waste Repository Authority (RAWRA) is a state organisation responsible for the management of activities related to the disposal of all Ski de fond - Accessoires - Sac a botte existing and future radioactive waste and spent nuclear fuel classed as a waste in Czech Republic.Worldwide, a deep geological repository is considered the hig

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